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| Cullin-RING E3 ligases | RING | Protein | Adaptor | Substrate recognition |
|---|---|---|---|---|
| CRL1/SCF | ROC1/Rbx1 | CUL1 | Skp1 | F-box protein |
| CRL2 | ROC1/Rbx1 | CUL2 | EloC/EloB | VHL box |
| CRL3 | ROC1/Rbx1 | CUL3 | BTB | BTB |
| CRL4 (A/B) | ROC1/Rbx1 | CUL4 | DDB1 | DCAF |
| CRL5 | ROC2/Rbx2 | CUL5 | EloC/EloB | SOCS protein |
| CRL7 | ROC1/Rbx1 | CUL7 | Skp1 | Fbw8 |
| CRL9 | ROC1/Rbx1 | PARC | – | – |
