TABLE IV.

Total Prevalence of Amelia in 20 Surveillance Programs of the International Clearinghouse for Birth Defects Surveillance and Research

Surveillance program	Period	Births	Total number of cases	% of Total cases that were SB	% of Total cases that were ETOPFAa	Total prevalence per 100,000 births	95% CI
Canada Alberta	1980–2005	1,062,483	17	23.5	41.2	1.60	0.93–2.56
USA Utah	1997–2004	380,706	2	50.0	0	0.53	0.06–1.90
USA Atlanta	1968–2004	1,283,999	20	25.0	31.6	1.56	0.95–2.41
USA Texas	1996–2002	2,054,788	30	16.7	13.3	1.46	0.99–2.08
Mexico RYVEMCE	1978–2005	1,058,885	25	44.0	NP	2.36	1.53–3.49
South America ECLAMC	1982–2006	4,556,173	52	34.6	NP	1.14	0.85–1.50
Finland	1993–2004	713,494	9	0	44.4	1.26	0.58–2.39
Northern Netherlands	1981–2003	369,658	3	0	0	0.81	0.17–2.37
Germany Saxony–Anhalt	1980–2004	355,184	2	50.0	50.0	0.56	0.07–2.03
Slovak Republic	2000–2005	318,257	6	16.7	0	1.89	0.69–4.10
France Central East	1979–2004	2,500,214	46	2.2	63.0	1.84	1.35–2.45
Italy North East	1981–2004	1,186,497	5	0	20.0	0.42	0.14–0.98
Italy Emilia Romagna	1982–2004	558,176	9	0	22.2	1.61	0.74–3.06
Italy Tuscany	1992–2004	336,744	4	0	0	1.19	0.32–3.04
Italy Campania	1992–2004	643,962	3	0	33.3	0.47	0.10–1.36
Italy Sicily	1991–2002	216,257	4	0	25.0	1.85	0.50–4.74
Spain ECEMC	1980–2004	2,045,751	15	13.3	NR	0.73	0.41–1.21
Israel	1975–2005	151,562	3	0	33.3	1.98	0.41–5.78
China Beijing	1992–2005	1,927,622	47	44.7	NR	2.44	1.79–3.24
Australia Victoria	1983–2004	1,390,179	24	58.3	25.0	1.73	1.11–2.57
Total		23,110,591	326	25.8	19.0a	1.41	1.26–1.57

ECEMC, Estudio Colaborativo Español de Malformaciones Congénitas; ECLAMC, Estudio Colaborativo Latino-Americano de Malformaciones Congénitas; RYVEMCE, Registroy Vigilancia Epidemiológica de Malformaciones Congénitas; SB, stillbirths; ETOPFA, elective termination of pregnancy for fetal anomaly; CI, confidence interval; NP, not permitted; NR, not reported.

^aThe percentage computed on the 16 programs registering ETOPFA is 33.2% (n = 62/187).