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. Author manuscript; available in PMC: 2015 Jun 3.
Published in final edited form as: Eur J Neurosci. 2014 Feb;39(3):508–519. doi: 10.1111/ejn.12462

Figure 1.

Figure 1

List of human disorders that are frequently accompanied by skeletal pain. A major reason that skeletal pain occurs in such a diverse group of disorders is that the skeleton participates in a variety of functions including structural support, ambulation, protection of internal organs, mineral and growth factor storage and release, and the birth and maturation of blood cells. As the skeleton is composed of tissues with very unique microenvironments, (such as articular cartilage, periosteum, mineralized bone, and bone marrow) injury, aging or disease in any of these compartments can result in skeletal pain. For an extensive list of diseases that are frequently accompanied by skeletal pain, see http://www.rightdiagnosis.com/symptoms/bone_pain/common.htm in children, http://www.nof.org/articles/5 and for a list of rare (orphan) bone diseases that may be accompanied by skeletal pain, http://www.usbji.org/projects/RBDPN_op.cfm?dirID=252.