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Abridged general view for the interplay among miR-646, NOB1 and the MAPK pathway in ccRCC. miR-646 as a tumour suppressor by targeting NOB1, which decreased the tumorigenesis of RCC cells in vivo and in vitro through the modulation of the MAPK pathway. Overexpression of miR-646, which suppresses the expression of NOB1, activates the MAPK pathway by increasing the phosphorylation of ERK1/2, JNK and p38 MAPK, which inhibits cell proliferation and induced apoptosis in human ccRCC.
