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. 2014 Jul 15;111(6):1139–1149. doi: 10.1038/bjc.2014.385

Figure 3.

Figure 3

Inhibition of FDPS radiosensitises PC cells. (Left) CSAs of radioselected Panc-1RR, BxPC3, fractionated BxPC3-RR, UN-KPC-961, and radioselected L3.6-RR cells following radiation treatment in the absence (control) and presence of indicated concentration of ZOL. ZOL treatment was 24 h before and 72 h after radiation treatment for Panc-1RR, BxPC3, fractionated BxPC3-RR, and 72 h after radiation treatment for UN-KPC-961 and radioselected L3.6-RR cells. Surviving fraction is expressed relative to non-irradiated cells in the respective treatment group. Graph shows the mean±s.e. of triplicate samples of a representative experiment. Asterisks indicate P-value <0.05. (Right) ER for each cell line following ZOL treatment. A value significantly >1 indicates radiosensitisation.