Figure 4.
Effect of ZOL on radiation therapy of subcutaneous mouse allograft tumours. Immune-competent mice were injected s.c. with UN-KPC-961 cells in two areas – one to be irradiated and one as unirradiated control. Half of the mice were given ZOL (2 mg kg−1) 1–2 h before the first radiation dose. Each mouse was aligned to its CT scan by ExacTrac and then stereotactically irradiated on 5 consecutive days with 7 Gy fractions. Waterfall plot showing percentage change in tumour volume at day 17 as observed by caliper measurement of tumours for all mouse tumours examined in the study. Similar results were observed with volume measured by CT imaging. Median of each treatment group is marked with ‘m'.