Table 3. DFS, DMFS and OS HRs according to EBV DNA tertiles.
|
EBV DNA tertile, copies ml−1, n=2563 |
||||
|---|---|---|---|---|
| 1 | 2 | 3 | ||
| <326 | 326–11 333 | ⩾11 333 | P (trend) | |
|
DFS | ||||
| TNM stage-adjusteda | 1.00 | 1.49 (1.12–1.98) | 4.24 (3.27–5.49) | <0.001 |
| Plus risk factorsb | 1.00 | 1.46 (1.10–1.95) | 4.04 (3.10–5.27) | <0.001 |
| Plus Fibrinogenc | 1.00 | 1.45 (1.09–1.94) | 3.91 (2.99–5.10) | <0.001 |
|
DMFS | ||||
| TNM stage-adjusteda | 1.00 | 1.94 (1.32–2.85) | 5.51 (3.88–7.84) | <0.001 |
| Plus risk factorsb | 1.00 | 1.95 (1.32–2.87) | 5.34 (3.72–7.66) | <0.001 |
| Plus Fibrinogenc | 1.00 | 1.92 (1.31–2.83) | 5.12 (3.57–7.35) | <0.001 |
|
OS | ||||
| TNM stage-adjusteda | 1.00 | 1.29 (0.78–2.11) | 4.38 (2.86–6.70) | <0.001 |
| Plus risk factorsb | 1.00 | 1.28 (0.78–2.11) | 3.98 (2.57–6.16) | <0.001 |
| Plus Fibrinogenc | 1.00 | 1.25 (0.76–2.06) | 3.76 (2.42–5.82) | <0.001 |
Abbreviations: DFS=disease-free survival; DMFS=distant metastasis-free survival; EBV DNA=Epstein–Barr Virus DNA; HR, hazard ratio, OS=overall survival; TNM stage=clinical stage for NPC based on the seventh American Joint Committee on Cancer (AJCC) TNM staging manual.
The values represent hazard ratios (95% confidence interval).
Obtained from Cox proportional hazard regression models adjusted for TNM stage (IV vs III vs II vs I).
Obtained from Cox proportional hazard regression models adjusted for age (⩾46 years vs <46 years), sex (male vs female), WHO pathological type (undifferentiated non-keratinising vs differentiated non-keratinising vs keratinising squamous cell), ECOG performance status (2 vs 0–1), chemoradiotherapy (yes vs no), radiation technique (intensity-modulated radiotherapy vs 3D-CRT/2D-CRT), lactate dehydrogenase (⩾170 U l−1 vs <170 U l−1), viral capsid antigen (⩾1 : 80 vs<1 : 80); early antigen (⩾1 : 10 vs<1 : 10), body mass index (⩾23 kg m−2 vs <23 kg m−2), smoking status (yes vs no), concurrent cardiovascular disease (yes vs no), diabetes (yes vs no), chronic hepatitis disease (yes vs no) and family history of NPC (yes vs no). The lowest tertile of each biomarker served as the reference category for the hazard ratios. P-values were obtained from models used to assess linear trends.
Adjusted for all the above variables and fibrinogen.