Figure 3.

Univariate performance of 39 biomarkers measured in both low- (L TMA; black bars) and high-(H TMA; brown bars) Gleason areas for disease aggressiveness and disease-specific mortality. (A) The odds ratio (OR) for predicting severe disease pathology (aggressiveness) was calculated for each marker. Markers with an OR to the left of the vertical line are negatively correlated with the severity of the disease as assessed by pathology. Those to the right of the line are positively correlated. The markers were ranked based on OR when measured in L TMA. (B) The hazard ratio for death from disease (lethality) was calculated for each marker and plotted as described for A. Biomarkers in red indicate statistical significance at the 0.1 level in both L and H TMAs. Biomarkers in blue indicate statistical significance in only H TMA, but not L TMA. Note the large overlap of biomarkers with statistically significant univariate performance for both aggressive disease and death from disease.