Figure 5.

Final biomarker set and selection criteria. (A) Twelve biomarkers were selected based on univariate performance for aggressiveness (shown as OR on left) and lethality as well as frequency of appearance in multivariate models for disease aggressiveness or lethal outcome (table on right) (B) The biomarker set comprises proteins known to function in the regulation of cell proliferation, cell survival, and metabolism. (C) A multivariate 12-marker model for disease aggressiveness was developed based on logistic regression. The resulting AUC and OR are shown. Subsequently, the risk scores generated by the aggressiveness model for all patients were correlated with lethal outcome. The resulting AUC and HR are shown.