Table 3. ORs and 95% CIs for TV watching and risk of adenoma by anatomic location, HPFS 1988–2008.

	Sitting while watching (h per week)
	0–6	7–13	14–20	21+	Ptrend	Per 14-h per week increment
Proximal colon
No. of cases (n=2257)	824	809	445	179
Age adjusteda	1.00 (ref.)	1.07 (0.97–1.18)	1.22 (1.08–1.37)	1.22 (1.03–1.44)	<0.001	1.24 (1.09–1.42)
Multivariateb	1.00 (ref.)	1.04 (0.94–1.15)	1.17 (1.04–1.32)	1.17 (0.98–1.38)	0.005	1.13 (1.04–1.24)
Multivariateb with physical activity and BMI	1.00 (ref.)	1.04 (0.94–1.15)	1.16 (1.03–1.31)	1.15 (0.97–1.37)	0.01	1.12 (1.03–1.23)
Distal colon
No. of cases (n=2092)	738	781	402	171
Age adjusteda	1.00 (ref.)	1.16 (1.05–1.29)	1.17 (1.03–1.32)	1.19 (1.00–1.42)	0.003	1.14 (1.05–1.24)
Multivariateb	1.00 (ref.)	1.12 (1.01–1.24)	1.09 (0.96–1.24)	1.08 (0.99–1.17)	0.10	1.08 (0.99–1.17)
Multivariateb with physical activity and BMI	1.00 (ref.)	1.12 (1.01–1.24)	1.09 (0.96–1.24)	1.10 (0.93–1.31)	0.11	1.07 (0.98–1.17)
Rectum
No. of cases (n=734)	250	266	161	57
Age adjusteda	1.00 (ref.)	1.17 (0.99–1.40)	1.38 (1.13–1.69)	1.18 (0.88–1.58)	0.004	1.22 (1.07–1.39)
Multivariateb	1.00 (ref.)	1.13 (0.95–1.35)	1.30 (1.06–1.60)	1.10 (0.82–1.48)	0.03	1.16 (1.01–1.33)
Multivariateb with physical activity and BMI	1.00 (ref.)	1.13 (0.95–1.35)	1.30 (1.06–1.59)	1.10 (0.82–1.48)	0.04	1.16 (1.01–1.33)

Abbreviations: BMI=body mass index; CI=confidence interval; HPFS=Health Professionals Follow-up Study; OR=odds ratio; ref.=referent.

^aAdjusted for age, time period of endoscopy, number of reported endoscopies, time since most recent endoscopy, and reason for current endoscopy.

^bAdditionally adjusted for family history of colorectal cancer, history of diabetes, height, alcohol intake, smoking, aspirin use, total calorie, folate, calcium intake, and red and processed meat intake.