Table 5. Joint analysis of TV watching and leisure-time physical activity on risk of adenoma, HPFS 1988–2008.
Sitting while watching TV (h per week) |
||||
---|---|---|---|---|
0–6 | 7–13 | 14+ | Pinteraction | |
Physical activitya
(MET-h per week) | ||||
Total adenoma (n=4280) | ||||
Q5 | ||||
No. of cases | 279 | 288 | 195 | 0.98 |
OR (95% CI) | 1.00 (ref.) | 1.06 (0.90–1.26) | 1.08 (0.89–1.30) | |
Q4 | ||||
No. of cases | 311 | 292 | 217 | |
OR (95% CI) | 1.10 (0.93–1.31) | 1.08 z(0.91–1.28) | 1.19 (0.99–1.43) | |
Q3 | ||||
No. of cases | 304 | 306 | 246 | |
OR (95% CI) | 1.07 (0.90–1.27) | 1.10 (0.93–1.31) | 1.33 (1.11–1.59) | |
Q2 | ||||
No. of cases | 308 | 339 | 241 | |
OR (95% CI) | 1.04 (0.88–1.23) | 1.26 (1.07–1.49) | 1.24 (1.03–1.49) | |
Q1 | ||||
No. of cases | 332 | 340 | 282 | |
OR (95% CI) | 1.10 (0.93–1.30) | 1.27 (1.07–1.50) | 1.25 (1.05–1.49) | |
High-risk adenoma (n=1833) | ||||
Q5 | ||||
No. of cases | 116 | 107 | 81 | 0.91 |
OR (95% CI) | 1.00 (ref.) | 0.91 (0.69–1.19) | 0.98 (0.73–1.31) | |
Q4 | ||||
No. of cases | 128 | 115 | 98 | |
OR (95% CI) | 1.07 (0.83–1.38) | 0.96 (0.74–1.25) | 1.15 (0.87–1.51) | |
Q3 | ||||
No. of cases | 125 | 125 | 104 | |
OR (95% CI) | 1.02 (0.79–1.33) | 1.02 (0.79–1.32) | 1.20 (0.92–1.58) | |
Q2 | ||||
No. of cases | 122 | 147 | 102 | |
OR (95% CI) | 0.93 (0.72–1.21) | 1.22 (0.95–1.57) | 1.10 (0.83–1.45) | |
Q1 | ||||
No. of cases | 155 | 167 | 141 | |
OR (95% CI) | 1.10 (0.86–1.41) | 1.34 (1.04–1.71) | 1.29 (1.00–1.66) | |
Low-risk adenoma (n=1606) | ||||
Q5 | ||||
No. of cases | 123 | 121 | 71 | 0.30 |
OR (95% CI) | 1.00 (ref.) | 1.05 (0.81–1.35) | 0.97 (0.72–1.30) | |
Q4 | ||||
No. of cases | 108 | 125 | 77 | |
OR (95% CI) | 0.89 (0.69–1.16) | 1.09 (0.85–1.41) | 1.06 (0.79–1.42) | |
Q3 | ||||
No. of cases | 122 | 115 | 88 | |
OR (95% CI) | 1.00 (0.78–1.30) | 0.99 (0.77–1.29) | 1.19 (0.90–1.58) | |
Q2 | ||||
No. of cases | 122 | 125 | 91 | |
OR(95% CI) | 0.98 (0.76–1.27) | 1.12 (0.87–1.45) | 1.19 (0.90–1.58) | |
Q1 | ||||
No. of cases | 117 | 109 | 92 | |
OR (95% CI) | 0.96 (0.74–1.25) | 1.01 (0.77–1.32) | 1.06 (0.80–1.40) |
Abbreviations: BMI=body mass index; CI=confidence interval; HPFS=Health Professionals Follow-up Study; MET=metabolic equivalent of task; OR=odds ratio; ref.=referent.
Quintiles of physical activity were defined biennially among men who reported to have an endoscopy during the period. Median physical activity levels (MET-h per week) across quintiles were 67.6 (Q5), 39.7 (Q4), 25.9 (Q3), 15.9 (Q2) and 6.6 (Q1). The model was adjusted for age, time period of endoscopy, number of reported endoscopies, time since most recent endoscopy and reason for current endoscopy, family history of colorectal cancer, history of diabetes, height, alcohol intake, smoking, aspirin use, total calorie, folate, calcium intake, red and processed meat intake, and BMI.