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. 2015 Jan 22;112(5):857–865. doi: 10.1038/bjc.2015.5

Figure 1.

Figure 1

Association between genotype and CPT-11 and metabolite plasma concentrations. (A) Effect of ABCB1 3435C>T genotype on dose-normalised CPT-11 plasma levels. Association between SLCO1B1 521T>C (B) and UGT1A1*28 (C) genotype and dose-normalised SN-38 levels. Effect of increasing number of combined SLCO1B1 521C and UGT1A1*28 variant alleles on dose-normalised SN-38 plasma levels (D) and plasma SN-38-G/SN-38 ratio (E). (F) Association between ABCC5 rs562 T>C genotype and SN-38-G plasma levels. *<0.05, **<0.01, ***<0.001.