Table 3. Multiple linear regression model for effect on Ln-transformed SN-38 concentration (adjusted R squared 0.2686), (n =127).

Predictor variable	Estimate	Standard error	P
Intercept	−0.732	0.269	<0.01
FOLFIRI regimen	0.160	0.104	0.124
FOLFIRINOX regimen	−0.108	0.120	0.367
Other CPT-11 regimena	0.037	0.146	0.802
Male sex	0.092	0.079	0.250
Age	0.008	0.004	0.063
ABCB1 c.3435 (C/T)	0.015	0.096	0.872
ABCB1 c.3435 (T/T)	−0.202	0.112	0.074
SLCO1B1 c.521 (T/C;C/C)	0.269	0.080	0.001
UGT1A1 (*1/*28)	0.200	0.077	0.011
UGT1A1 (*28/*28)	0.456	0.137	0.001
CES1 rs71647871 (G/A)	−0.341	0.171	0.048

Abbreviations: FOLFIRI=5-fluorouracil, irinotecan, leucovorin; FOLFIRINOX=5-fluorouracil, irinotecan, leucovorin, oxaliplatin.

^aOther CPT-11 regimen includes irinotecan as a single agent, irinotecan +cetuximab, 5-FU-irinotecan +cetuximab.