Table 4. Association between genotype and toxicity (n =127).
| Toxicity and covariate | OR | 95% CI | Multivariate Pa | Univariate P |
|---|---|---|---|---|
|
Binary logistic regression (low vs high)b | ||||
| Neutropenia | ||||
| UGT1A1*28 carriers | 3.67 | 1.19—11.33 | <0.05 | <0.05 |
|
Multinomial logistic regression (no event vs low vs high)c | ||||
| Neutropenia | ||||
| ABCC2–24 C/T | 0.22 | 0.06—0.85 | <0.05 | 0.07 |
| ABCC2–24 T/T | 0.84 | 0.63—1.23 | 0.85 | 0.08 |
| Diarrhoea | ||||
| CES1 rs2244613 | 0.29 | 0.09—0.89 | <0.05 | <0.05 |
| Nausea/vomiting | ||||
| ABCB1 3435 C/T | 9.06 | 1.03—79.41 | 0.06 | 0.09 |
| ABCB1 3435 T/T | 10.52 | 1.10—100.2 | <0.05 | 0.05 |
| Oral mucositis | ||||
| CYP3A5*3 | 8.1 | 1.57—41.90 | <0.05 | <0.05 |
| SLCO1B1 388A/G | 0.19 | 0.05—0.72 | <0.05 | <0.05 |
| SLCO1B1 388G/G | 0.62 | 0.13—2.99 | 0.55 | 0.74 |
Abbreviations: OR=odds ratio; CI=confidence interval.
a
Adjusted for age at enrolment, sex, and treatment regimen.
b
Low=grades 0, 1, and 2; high grade=grade 3 and 4.
c
Results are shown for no event vs high regression where high was considered as grade 3/4 (neutropenia) and grade 2/3 (diarrhoea, nausea/vomiting, and oral mucositis).