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. 2015 May 25;56(5):3361–3370. doi: 10.1167/iovs.14-15692

Figure 7.

Figure 7

Model for the role of Cdc42 and exocyst Sec10 in delivery of proteins. The connecting cilium originates from the basal body in the IS, and the axoneme extends into the OS. (A) An illustration of the photoreceptor and retinal pigmented cell structures. (B) The illustration focuses on the connecting cilium, a region of disk morphogenesis and protein transport. Vesicles containing rhodopsin/OS membrane proteins express Rab8 on the vesicle surface, and Rab8, in turn, is regulated by Rabin8 and Rab11. The exocyst complex is localized to the primary cilium by Cdc42, and then targets and docks vesicles carrying rhodopsin/OS membrane proteins. This occurs because exocyst Sec15 interacts with Rab8 found on the vesicle surface. Sec10 then binds to Sec15, and pulls the vesicle to the rest of the exocyst complex located at the cilium.