Table 3. Frequencies of mtDNA M/N haplogroups in Han Chinese patients with SLE and specific clinical manifestations of the disease.
| Manifestation | mtDNA M/N haplogroup frequency, n (%) | χ2 | P | OR# | 95% CI | |||
|---|---|---|---|---|---|---|---|---|
| Patients with manifestation | Patients without manifestation | |||||||
| N(%) | M(%) | N(%) | M(%) | |||||
| Onset age < 30 years | 203 (49.8) | 205 (50.2) | 236 (51.3) | 224 (48.7) | 0.208 | 0.649 | 0.94 | 0.72 to 1.227 |
| Lupus nephropathy | 260 (50.0) | 260 (50.0) | 169 (48.6) | 179 (51.4) | 0.172 | 0.678 | 1.059 | 0.807 to 1.390 |
| anti-dsDNA ( + ) | 225 (49.3) | 231 (50.7) | 203 (49.3) | 209 (50.7) | 0.000 | 0.984 | 1.003 | 0.768 to 1.309 |
| Hematological system damage | 344 (63.9) | 194 (36.1) | 150 (45.5) | 180 (54.5) | 28.504 | < 0.001* | 2.128 | 1.610 to 2.813 |
| Arthritis | 236 (46.9) | 267 (53.1) | 193 (52.9) | 172 (47.1) | 3.004 | 0.083 | 0.788 | 0.601 to 1.032 |
| Skin impairment | 293 (60.3) | 193 (39.7) | 171 (44.8) | 211 (55.2) | 20.716 | < 0.001* | 1.873 | 1.428 to 2.457 |
| Alopecia | 192 (55.3) | 155 (44.7) | 252 (48.3) | 269 (51.7) | 4.041 | 0.044* | 1.322 | 1.007 to 1.737 |
| Photosensitivity | 79 (57.1) | 60 (42.9) | 359 (49.2) | 370 (50.8) | 2.690 | 0.101 | 1.357 | 0.941 to 1.956 |
| Oral ulcer | 35 (40.2) | 52 (59.8) | 387 (49.6) | 394 (50.4) | 2.723 | 0.099 | 0.685 | 0.437 to 1.076 |
| Nervous system disturbances | 34 (79.1) | 9 (20.9) | 403 (48.8) | 422 (51.2) | 14.932 | < 0.001* | 3.956 | 1.874 to 8.352 |
| Raynaud phenomenon | 18 (42.9) | 24 (57.1) | 411 (49.8) | 415 (50.2) | 0.761 | 0.383 | 0.757 | 0.405 to 1.416 |
*P < 0.05.
#ORs refer to the risk associated with the mtDNA N haplogroup relative to the mtDNA M haplogroup.