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. 2015 Jun 3;5:10804. doi: 10.1038/srep10804

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Copyright © 2015, Macmillan Publishers Limited

This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/

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Fic/Doc sequences were manually clustered based on their motifs. Consensus motifs of each of the 5 clusters obtained were mapped on to the Fic/Doc phylogenetic tree using various colors. Active sites of each of the 5 clusters have been mapped on available 3D structures or modeled structures. The legend represents the consensus motif. HMM logo for Fic motif of each clade has also been represented here. As clade F6 did not have a conserved Fic motif the HMM logo was not represented.