Figure 6. Occurrence of Fic/Doc proteins on genomic islands.

(A) Bar plot depicts number of genomes containing different number of mobility genes in the neighborhood of Fic/Doc domain containing genes. (B) Circular map of Escherichia coli APEC O1 chromosome depicting genomic island as predicted by IslandViewer. The lines on the inner circles are colored based on the tools used for prediction. The wavy black line indicates variation of %GC content. The pink lines on the outer circle indicate location of genomic island as predicted by IslandViewer ⁴³,⁴⁴. Fic protein of E. coli APEC O1 (Nucleotide position: 1480490 to 1480975) is marked by an arrow and it lays within region of predicted genomic island. (C) Genome alignment of Fic containing E. coli APEC O1 and E. coli SMS-3-5 (lacks Fic) using progressive Mauve ⁶³,⁶⁴. Similar colored blocks in two genomes connected by lines represent homologous regions. The genomic regions in E. coli SMS-3-5 which are inverted with respect to E. coli APEC O1 are represented as blocks below the central line. The position of Fic protein in E. coli APEC O1 is shown. This region does not correspond to any homologous region in E. coli SMS-3-5 which lacks Fic. Probable site of insertion of this region has also been marked on E. coli SMS-3-5 genome.