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. 2015 May 26;8:1193–1210. doi: 10.2147/OTT.S82936

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© 2015 Lien et al. This work is published by Dove Medical Press Limited, and licensed under Creative Commons Attribution – Non Commercial (unported, v3.0) License

The full terms of the License are available at http://creativecommons.org/licenses/by-nc/3.0/. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed.

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The schematic diagram illustrates that oral treatment with the herbal formula B307 alleviates cardiotoxicity in doxorubicin-treated mice via suppressing hypoxia, oxidative stress, inflammation, and apoptosis in the heart tissue.

Abbreviations: eNOS, endothelial nitric oxide synthase; SOD2, superoxide dismutase 2; ROS, reactive oxygen species; 3-NT, neurotrophin-3; 4-HNE, 4-hydroxynonenal; NF-κB, nuclear factor-κB; TNF-α, tumor necrosis factor alpha; er, endoplasmic reticulum; Bcl-2, B-cell lymphoma 2; Bax, Bcl-2-associated X protein; Cyto-C, cytochrome C.