Table 1.
Clinical efficacy studies of tetracycline/doxycycline, alone or versus macrolides, for treatment of Mycoplasma genitalium infection
| Reference | Year | Study type | Population | M. genitalium cases (n) | Tetracycline regimen(s) and M. genitalium microbiological cure | Macrolide regimen and M. genitalium microbiological cure |
|---|---|---|---|---|---|---|
| Horner et al10 | 1993 | Prospective case–control study | 164 men with/without NGU attending an STI clinic, UK | 27 men | DOXY 200 mg d 1, 100 mg d 2–d 9 10/14 cured (71.4%) |
Not applicable |
| Johannisson et al18 | 2000 | Uncontrolled observational study | 233 men and 85 women attending STI clinics, Sweden | 18 men 3 women |
TET 500 mg 12 hourly ×10 d 5/13 men cured (38.5%) 0/1 women cured (0%) |
Not applicable |
| Gambini et al19 | 2000 | Prospective study with treatment varying by room | 201 men with/without NGU attending an STI clinic, Italy | 53 men | DOXY 200 mg/day ×7 d 33/35 cured (94.3%) |
AZM 1 g stat 14/17 cured (82.4%) |
| Falk et al17 | 2003 | Uncontrolled observational study | 519 men and 464 women attending an STI clinic, Sweden | 34 men 26 women |
DOXY 200 mg d 1, 100 mg d 2–d 9 or LYME 300 mg 12 hourly ×10 d Men: 6/16 cured (37.5%) Women: 4/14 cured (28.6%) |
AZM 500 mg d 1, 250 mg d 2–d 5 Men: 16/16 cured (100.0%) Women: 20/20 cured (100.0%) |
| Björnelius et al20 | 2008 | Uncontrolled observational study | 152 men with NGU and 60 women with cervicitis attending 6 STI clinics, Norway and Sweden | 152 men 60 women |
DOXY 200 mg (d 1), 100 mg (d 2–d 9) Men: 13/76 cured (17.1%) Women: 10/27 (37.0%) |
AZM 1 g stat Men: 33/39 cured (84.6%) Women: 15/17 cured (88.2%) |
| Mena et al21 | 2009 | Randomized controlled trial | 398 men with NGU attending an STI clinic, USA | 78 men | DOXY 100 mg 12 hourly ×7 d 14/31 cured (45.2%) |
AZM 1 g stat 20/23 cured (87.0%) |
| Schwebke et al22 | 2011 | Randomized controlled trial | 305 men with NGU attending 4 STI clinics, USA | 94 men | DOXY 100 mg 12 hourly ×7 d (± tinidazole 2 g stat) 12/39 cured (30.8%) |
AZM 1 g stat (± tinidazole 2 g stat) 30/45 cured (66.7%) |
| Manhart et al23 | 2013 | Randomized controlled trial | 606 men with NGU attending an STI clinic, USA | 80 men | DOXY 100 mg 12 hourly ×7 d (+ AZM placebo) 8/27 cured (29.6%, mITT) |
AZM 1 g stat (+ DOXY placebo) 15/38 cured (39.5%, mITT) |
Abbreviations: M. genitalium, Mycoplasma genitalium; NGU, non-gonococcal urethritis; STI, sexually transmitted infection; DOXY, doxycycline; TET, tetracycline; LYME, lymecycline; AZM, azithromycin; d, day/days; mITT, modified intention to treat population.