Table I. eCB-LTD is a widespread phenomenon the brain.
Examples of eCB-LTD confirmed using CB1R antagonists, CB1R knockout mice or both. STDP, spike timing-dependent plasticity; HFS, high-frequency stimulation (100 Hz); LFS, low-frequency stimulation (1 Hz).
| Brain Structure | Synapse | Induction protocol | References |
|---|---|---|---|
| Neocortex | |||
| Visual | Excitatory inputs, L5 pyramidal cell-pairs | STDP (postsynaptic bursts) STDP and LFS |
(26, 27) (28) |
| Excitatory inputs, L4 → L2/3 pyramidal neurons (immature visual cortex) | TBS | (29) | |
| Somatosensory (barrel cortex) | Excitatory inputs to L2/3 pyramidal neurons | STDP (postsynaptic bursts) | (30, 31) |
| Prefrontal | L2/3 → L5/6 | Moderate 10 Hz stimulation for 10 min | (32) |
| Hippocampus | Inhibitory inputs to CA1 pyramidal cells | HFS, TBS | (20-22, 24, 25) |
| Excitatory inputs to CA1 pyramidal cells (immature hippocampus) | HFS | (23) | |
| Amygdala | Inhibitory inputs to basolateral amygdala | LFS | (17-19) |
| Dorsal Striatum | Excitatory inputs to medium spiny neurons | LFS, STDP | (15, 39, 49, 50) |
| Nucleus Accumbens | Excitatory inputs to medium spiny neurons | Moderate 13 Hz stimulation for 10 min | (16, 142) |
| Cerebellum | Excitatory inputs to Stellate Interneurons | 4 bouts of 25 stimuli at 30 Hz, delivered at 0.33 Hz | (33) |
| Ventral Tegmental Area (VTA) | Inhibitory inputs to dopamine neurons | Moderate 10 Hz stimulation for 5 min | (34) |
| Dorsal Cochlear Nucleus | Excitatory inputs to Cartwheel cells | STDP | (35) |
| Superior Colliculus | Inhibitory inputs to tectal neurons in vitro | HFS | (36) |