Table 1.
Genetic | |
LQT3 | Direct Biophysical |
LQT9 | Enhanced Nitrosylation |
LQT10 | ? |
LQT12 | Enhanced Nitrosylation |
Acquired | |
Hypertrophy | Stretch, altered signaling, remodeling |
Heart Failure | Stretch, altered signaling, remodeling |
Ischemia | Acidosis, metabolites (LPC) |
Diabetes | Cardiomyopathy, altered signaling |
Molecules | |
Carbon Monoxide | ? |
Acidosis | ? |
LPC (ischemic metabolite) | PKC? |
ROS (H2O2) | CamK? |
Drugs | |
Dofetilide | PI3K inhibition |
Sotalol | PI3K inhibition |
Erythromycin | PI3K inhibition |
Thioridazine | PI3K inhibition |
Nilotinib | PI3K inhibition |
Cell signaling | |
nNOS Nitrosylation | direct on NaV1.5 |
CamK Phosphorylation | direct on NaV1.5 |
PI3K-Akt pathway inhibition | ? |
PKC Phosphorylation | direct on NaV1.5 |