Table 2.
Drug | Ratio Late:Peak IC50 |
Late INa
IC50 μM |
Therapeutic concentration range μM |
---|---|---|---|
Block of late INa | |||
Ranolazine | 38 - 61 | 7 | 0.4 - 6.1 |
Amiodarone | 13 - 60 | 3 - 6.7 | 0.8 - 3.9 |
Mexilitene | 9 - 51 | 3 - 5 | 3.4 - 9.5 |
Lidocaine | 3 - 12 | 25 | 0.8 - 4.2 |
Propranalol | 7 | 3 | 0.1 – 0.4 |
Flecainide | 3 - 7 | 1.4 | 0.5 - 2.4 |
Vernakalant | 3 - 5 | 30 | 7.2 - 14.3 |
Quinidine | 1 | 12 | 9.3 - 24.7 |
Increased Late INa | |||
Dofetilide | .103 | .005-.023 | |
Nilotinib | 1.0 | 1.7-62 |