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. 2014 Aug 7;5(8):e1360. doi: 10.1038/cddis.2014.326

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Copyright © 2014 Macmillan Publishers Limited

Cell Death and Disease is an open-access journal published by Nature Publishing Group. This work is licensed under a Creative Commons Attribution-NonCommercial-ShareAlike 3.0 Unported License. The images or other third party material in this article are included in the article's Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by-nc-sa/3.0/

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Functional domains of E2F transcription factor family. On the basis of their ability to regulate downstream target genes, E2F family members are classified into two groups, activators (E2F1-3a) or repressors (E2F3b-8). As transcription factors, they all have the DBD, NLS, DD (dimerization domain), TAD, NES (nuclear exclusion signal; modified from Chen et al.²)