Bladder cancer |
Controversial in publications |
Low E2F1 reactivity in tumor caused increased risk of progression to metastasis;84 expression correlated with proliferation in superficial TCCs85
|
Breast cancer |
Increase85, 86, 87
|
Poor survival and prognostic indicator;85, 86, 87 overexpression induced apoptosis in human breast cancer cells88
|
Cervical cancer |
Increase; gene amplification89, 90, 91
|
Aberrant cell cycle regulation;92 mediates overexpression of emerging markers for detection of high-grade cervical disease93 mediates miRNAs in response to HPV E794
|
Colon cancer |
Decrease2, 11
overexpression in lung and liver metastases of human colon cancer95
|
Inversely associated with tumor growth;85, 96 upregulates c-Myc and p14ARF and induces apoptosis in colon cancer cells97
|
Esophageal cancer |
Increase; gene amplification98
|
Poor survival;99, 100 positively associated with cell proliferation but not apoptosis;101 however, positively correlates with apoptosis and inversely correlates with cell proliferation in adenocarcinomas of Barrett esophagus102
|
Gastric adenocarcinoma |
Increase103, 104, 105
Higher expression in early stage I–II and lower expression in later stages106
|
Adenovirus-mediated E2F1 overexpression induces apoptosis;107 overexpression suppresses tumor cell proliferation108, 109
|
GI stromal cancer |
Increase110
|
Increased cell proliferation and adverse prognosis110, 111
|
Glioblastoma |
Increase112
|
Overexpression increases chemosensitivity113
|
Hepatocellular carcinoma (HCC) |
Increase; gene amplification114, 115, 116
|
Correlated with enhanced tumor cell apoptosis;114 tumor-promoting roles in HCC cell lines or mouse models117, 118, 119, 120, 121
|
Lung cancerNSCLC |
Increase;122, 123 gene amplification124
|
Growth-promoting factor associated with poor prognosis;125 overexpression induces apoptosis126
|
SCLC |
Increase100, 127
|
Involved in tumorigenesis by activation of EZH2 oncogene EZH2128, 129, 130
|
Melanoma |
Increase; gene amplification42, 47
|
Overexpression induces apoptosis and growth inhibition;73, 131, 132, 133 induces autophagy;11 controls proliferation by regulating AKT phosphorylation;66 associated with progression and metastasis50
|
Oral SCC |
Increase134
|
Associated with increased overall survival135
|
Ovarian cancer |
Increase136, 137, 138
|
Overexpression induces apoptosis in human ovarian cancer cells;88 mediates cell cycle deregulation in high-grade serous ovarian carcinomas;136 determines balance between proliferation and cell death139
|
Pancreatic ductal carcinoma |
Increase140
|
Tumor promoting and poor survival;59 overexpression induces apoptosis and increases chemosensitivity in pancreatic cancer cells60, 61
|