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SE-induced PARP activation (PAR synthesis) in the hippocampus and the PC in vivo. In non-SE animals, PAR immunoreactivity is rarely observed in the hippocampus and the PC. At 12 h after SE, PAR is detected in the CA1–3 neurons, dentate granule cells, hilar neurons and PC neurons. PAR immunoreactivity is also observed in some astrocytes in the CA1 region (arrows). Bar=25 μm
