Figure 1.

K-1 (2-[piperidinoethoxyphenyl]-3-[4-hydroxyphenyl]- 2H-benzo(b) pyran) inhibits endometrial hyperplasial cell proliferation. (a) Chemical structure of compound K-1, (b and c) cellular growth pattern of normal primary endometrial cells and primary endometrial hyperplasial cells. Cells were treated with various concentrations of compound K-1 (1, 2.5, 5, 7.5 and 10 μM) in the absence or presence of estradiol (10 nM) for 48 h. Cell viability was measured using MTT assay. The percentage of viable cells was calculated as the ratio of treated cells to the control cells. Data are expressed as mean (of three different experiments on normal samples and five different experiments on hyperplasial samples);±S.E.M., P values are a-P<0.001, b-P<0.01, c-P<0.05 and d-P>0.05 versus control and e-P<0.001, f-P<0.01, g-P<0.05 and h-P>0.05 versus estradiol