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. 2014 Aug 28;5(8):e1396. doi: 10.1038/cddis.2014.335

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Copyright © 2014 Macmillan Publishers Limited

Cell Death and Disease is an open-access journal published by Nature Publishing Group. This work is licensed under a Creative Commons Attribution-NonCommercial-ShareAlike 3.0 Unported License. The images or other third party material in this article are included in the article's Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by-nc-sa/3.0/

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Upregulation of poFUT1 by LIF promotes cell migration and invasion through PI3K/Akt signal pathway. (a) Trophoblast cells were pretreated by poFUT1-siRNA, LIF or inhibitor of PI3K (LY294002), and activation of PI3K/Akt signal molecules (p-PDK, p-Akt468, and p-Akt308) was measured by western blotting. (c and e) Invasion potential and MMP-2 activity and TIMP-1, -2 expression were detected. (b) Trophoblast cells pretreated by poFUT1 cDNA, LIF or inhibitor of PI3K, and activation of PI3K/Akt signal molecules was measured by western blotting. (d and f) Invasion potential and MMP-2 activity and TIMP-1, -2 expression were detected