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. 2014 Aug 14;5(8):e1374. doi: 10.1038/cddis.2014.336

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Copyright © 2014 Macmillan Publishers Limited

Cell Death and Disease is an open-access journal published by Nature Publishing Group. This work is licensed under a Creative Commons Attribution 3.0 Unported License. The images or other third party material in this article are included in the article's Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/3.0/

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The mAb_ED-C99 promotes APP β-secretase processing in vivo. TgAPP_wt female mice at 8 months of age were treated with mAb_ED-C99 or control IgG₁ at 5 μg/mouse by intracerebroventricular (i.c.v.) injection and killed 24 h after the treatment (n=6). (a) Cytosolic- (left panels) and membrane-associated proteins (right panels) prepared from mouse brain homogenates were subjected to WB analysis for APP processing. (b) For WB quantitative analysis, band density ratio of membrane-associated β-CTF to membrane-associated total APP was analyzed (upper panel). Aβ_40/42 was also analyzed by ELISA (lower panel, n=6). The results are presented as pg of Aβ_40/42 per mg of total intercellular proteins (mean±S.D.; ***P<0.001)