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. 2014 Aug 28;5(8):e1395. doi: 10.1038/cddis.2014.357

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Copyright © 2014 Macmillan Publishers Limited

Cell Death and Disease is an open-access journal published by Nature Publishing Group. This work is licensed under a Creative Commons Attribution-NonCommercial-ShareAlike 3.0 Unported License. The images or other third party material in this article are included in the article's Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by-nc-sa/3.0/

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Effects of Dock3 on myelin protection in the corpus callosum of a cuprizone-induced demyelinating model. (a and b) Brain coronal sections illustrating a high intensity of LFB (a) and MBP (b) in Dock3 Tg mice compared with WT mice after cuprizone treatment for 6 weeks. Right panels are higher magnifications of the boxes shown in the left panels. Scale bars: 150 μm in the left panels and 50 μm in the right panels. (c) Quantitative analysis of LFB- and MBP-intensities in a and b. (d) Western blot analysis displaying increased CNPase expression in the brain of Dock3 Tg mice after cuprizone treatment. The data are presented as mean±S.E.M. of six independent samples. The results are expressed as percentages of the normal WT mice. **P<0.01; *P<0.05