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. 2014 Aug 28;5(8):e1395. doi: 10.1038/cddis.2014.357

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Copyright © 2014 Macmillan Publishers Limited

Cell Death and Disease is an open-access journal published by Nature Publishing Group. This work is licensed under a Creative Commons Attribution-NonCommercial-ShareAlike 3.0 Unported License. The images or other third party material in this article are included in the article's Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by-nc-sa/3.0/

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Effects of Dock3 on Erk activation in optic nerves. (a–c) Western blot analysis of total and phosphorylated Erk (a), p38 (b) and JNK (c) in the optic nerves of WT and Dock3 Tg mice. Relative levels of phosphorylated proteins are quantified. The data are presented as mean±S.E.M. of six independent samples. The results are expressed as percentages of the WT mice. *P<0.05. (d) Optic nerve sections illustrating a high intensity of phosphorylated Erk in the optic nerve of Dock3 Tg mice compared with WT mice. Scale bar: 50 μm