Table 2.

Regions with significant longitudinal changes in glucose metabolism.

Regions	Coordinatesa			Zmax	P-valuec	Mean adjusted regional glucose metabolism (mg/min/100 g)
	x	y	z			Baseline (n = 15)	24 Months (n = 15)	48 Months (n = 10)	Controls (n = 15)
Increasing metabolism
Pons	−6	−38	−32	4.80	<0.001	8.16 ± 0.73*	8.77 ± 0.52***	9.32 ± 0.72***	7.68 ± 0.73
Cerebellum, Lobule VIb	30	−60	−46	4.29	<0.001	10.49 ± 0.88	11.02 ± 0.77	11.80 ± 1.00**	10.57 ± 0.91
Paracentral Gyrus (BA 4/6)	−6	−28	52	4.71	<0.001	13.50 ± 0.84	14.10 ± 0.80**	14.09 ± 0.86**	12.93 ± 1.17
Subthalamic nucleus	−10	−10	−4	4.35	0.020	10.49 ± 1.18	11.05 ± 0.90	11.68 ± 1.11**	10.41 ± 0.86
Globus Pallidus (internal)	20	−14	−2	3.85	0.023	10.49 ± 0.97	11.06 ± 0.94**	11.46 ± 1.24*	10.39 ± 0.65
Decreasing metabolism
Medial Frontal Lobe (BA 9/10)	8	62	22	4.96	<0.001	10.26 ± 0.81	9.57 ± 0.87	9.37 ± 1.09	10.27 ± 1.13
Inferior Parietal Lobule (BA 39/40)	−56	−56	40	4.23	0.008	12.11 ± 0.61	11.67 ± 0.56	11.39 ± 0.56*	12.15 ± 0.92

^aMontreal Neurological Institute (MNI) standard space; BA = Brodmann Area.

^bAccording to the atlas of Schmahmann (Schmahmann et al., 2000).

^cSPM, P-values corrected at the cluster level. All maxima were significant at P<0.01, FDR-corrected at the voxel level.

^*P<0.05,

^**P<0.01,

^***P<0.001, compared to age-matched healthy control values (Student’s t-tests).