Skip to main content
. Author manuscript; available in PMC: 2016 Jan 1.
Published in final edited form as: Clin Exp Pharmacol Physiol. 2015 Jan;42(1):14–21. doi: 10.1111/1440-1681.12319

Figure 4.

Figure 4

Expression of the (P)RR in medullary collecting ducts in normal rats (A) and Ang II infused rats for 14 days. Ang II infusion causes a decrease in the number of positive cells. Despite decrease in cells with immunoreactivity for (pro)renin receptor bound to the membrane, the soluble cleaved form of the (pro)renin receptor was augmented in medullary tissues and importantly detected in the urine of the Ang II infused rats (C). Ang II infusion for 14 days also causes the augmentation of renin and prorenin in the collecting ducts suggesting that (pro)renin receptor and renin can interact to contribute to Ang I formation and further Ang II generation (modified from Gonzalez et al., 2011).