Table 3.

Peak locations and structures of significant metabolic changes of mild cognitive impairment (MCI) in Parkinson disease

			Coordinates*
Group comparison	Structure	Z score	x	y	z
MD-MCI vs N-MCI
MD-MCI < N-MCI	Left inferior parietal lobulus (BA 7/40)	4.28†	−38	−62	60
	Supramarginal gyrus (BA 40)	3.60	−52	−58	34
	Right middle frontal gyrus (BA 8)	4.52‡	30	18	48
	Middle frontal gyrus (BA 9/46)	4.16	40	26	42
	Middle frontal gyrus (BA 46)	4.04	46	26	32
	Left middle frontal gyrus (BA 8/9)	3.60§	−30	24	46
MD-MCI > N-MCI	Left pons/cerebellum	4.36¶	−8	−34	−24
	Right pons/cerebellum	4.33	6	−38	−22
SD-MCI vs N-MCI
SD-MCI > N-MCI	Cingulate gyrus (BA 24/31)	3.94§	−10	−18	44
MD-MCI vs SD-MCI
MD-MCI < SD-MCI	Right middle frontal gyrus (BA 9)	4.11†	44	26	32
	Middle frontal gyrus (BA 9)	3.95	42	32	40
	Left inferior parietal lobulus (BA 40)	4.22§	54	−30	56
MD-MCI > SD-MCI	NA	NA	NA	NA	NA

Indented areas are submaxima of preceding cluster.

^*Montreal Neurological Institute standard space.

^†p < 0.05,

^‡p < 0.01,

^¶p < 0.001, Cluster corrected.

^§p < 0.05, Corrected for area.

MD-MCI=multiple domain MCI; N-MCI=without mild cognitive impairment; BA=Brodmann area; SD-MCI=single domain MCI.