Table 1. Fold change of top 10 genes induced and top 10 genes inhibited in the ALI after prolonged IL-13 exposure and altered in EoE.
Gene symbol | Fold change [day 14 untx] 1 | Fold change [day 14 + IL-13] 2 | Fold change [EoE] 3 | |
---|---|---|---|---|
Induced | SERPINB4 | -5.2 | 379.3 | 11.6 |
CAPN14 | -3.1 | 161.7 | 6.0 | |
TNFAIP6 | N/A | 141.0 | 52.7 | |
FETUB | N/A | 37.0 | 3.9 | |
SERPINB3 | -4.4 | 33.9 | 2.5 | |
CCL26 | N/A | 28.9 | 387.1 | |
CDH26 | 2.4 | 25.4 | 70.0 | |
IFIT1 | N/A | 16.8 | 2.3 | |
LBH | N/A | 16.6 | 9.3 | |
NTRK1 | N/A | 14.5 | 3.7 | |
Inhibited | KPRP | 70.5 | -84.8 | -10.9 |
FAM25A | 3.6 | -18.3 | -50.6 | |
RNASE7 | 82.8 | -18.2 | -11.7 | |
SPRR2B | 389.7 | -15.6 | -12.5 | |
IGFL1 | -15.3 | -13.0 | -17.6 | |
FLG | 10.9 | -10.9 | -15.9 | |
AX747517 | 4.8 | -8.0 | -2.3 | |
RNF223 | 9.2 | -7.1 | -7.0 | |
MT2A | -3.5 | -7.1 | -4.8 | |
IVL | N/A | -7.1 | -2.9 |