Table 3. Genotype and Allele distributions in patients with valvular calcification and control participants.
| Han | Uygur | Kazak | |||||||
|---|---|---|---|---|---|---|---|---|---|
| Variant | Valvular calcification(%) | control(%) | P value | Valvular calcification(%) | control(%) | P value | Valvular calcification(%) | control(%) | P value |
| rs1800871 | |||||||||
| Genotype | |||||||||
| TT | 107(55.2) | 167(40.6) | 13(22) | 27(20.3) | 31(38.3) | 48(25.7) | |||
| CC | 20(10.3) | 59(14.4) | 20(33.9) | 39(29.3) | 13(16) | 40(21.4) | |||
| CT | 67(34.5) | 185(45) | 0.004 | 26(44.1) | 67(50.4) | 0.714 | 37(45.7) | 99(52.9) | 0.108 |
| Dominant model | |||||||||
| CC | 20(10.3) | 59(14.4) | 20(33.9) | 39(29.3) | 13(16) | 40(21.4) | |||
| CT+TT | 174(89.7) | 352(85.6) | 0.168 | 39(66.1) | 94(70.7) | 0.526 | 68(84) | 147(78.6) | 0.313 |
| Recessive model | |||||||||
| TT | 107(55.2) | 167(40.6) | 13(22) | 27(20.3) | 31(38.3) | 48(25.7) | |||
| CT+CC | 87(44.8) | 244(59.4) | 0.001 | 46(78) | 106(79.7) | 0.785 | 50(61.7) | 139(74.3) | 0.038 |
| Additive model | |||||||||
| CT | 67(34.5) | 185(45) | 26(44.1) | 67(50.4) | 37(45.7) | 99(52.9) | |||
| CC+TT | 127(65.5) | 226(55) | 0.015 | 33(55.9) | 66(49.6) | 0.42 | 44(54.3) | 88(47.1) | 0.275 |
| Allele | |||||||||
| C | 107(27.6) | 303(36.9) | 66(55.9) | 145(54.5) | 63(38.9) | 179(47.86) | |||
| T | 281(72.4) | 519(63.1) | 0.001 | 52(44.1) | 121(45.5) | 0.796 | 99(61.1) | 195(52.14) | 0.055 |
| rs1800872 | |||||||||
| genotype | |||||||||
| CC | 64(33) | 63(15.3) | 31(52.2) | 46(34.6) | 36(44.4) | 55(29.4) | |||
| AA | 77(39.7) | 163(39.7) | 10(16.9) | 26(19.5) | 18(22.2) | 50(26.7) | |||
| AC | 53(27.3) | 185(45) | 0 | 18(30.5) | 61(45.9) | 0.056 | 27(33.3) | 82(43.9) | 0.056 |
| Dominant model | |||||||||
| CC | 64(33) | 63(15.3) | 31(52.2) | 46(34.6) | 36(44.4) | 55(29.4) | |||
| AC+AA | 130(67) | 348(84.7) | 0 | 28(47.5) | 87(65.4) | 0.019 | 45(55.6) | 132(70.6) | 0.017 |
| Recessive model | |||||||||
| AA | 77(39.7) | 163(39.7) | 10(16.9) | 26(19.5) | 18(22.2) | 50(26.7) | |||
| AC+CC | 117(60.3) | 248(60.3) | 0.994 | 49(83.) | 107(80.5) | 0.67 | 63(77.8) | 137(73.3) | 0.435 |
| Additive model | |||||||||
| AC | 53(27.3) | 185(45) | 18((30.5) | 61(45.9) | 27(33.3) | 82(43.9) | |||
| AA+CC | 141(72.7) | 226(55) | 0 | 41(69.5) | 72(54.1) | 0.046 | 54(66.7) | 105(56.1) | 0.107 |
| Allele | |||||||||
| C | 181(46.6) | 311(37.8) | 80(67.8) | 153(57.5) | 99(61.1) | 192(51.3) | |||
| A | 207(53.4) | 511(62.2) | 0.004 | 38(32.2) | 113(42.5) | 0.057 | 63(38.9) | 182(48.7) | 0.037 |