Table 3.
Odds ratios (95% CI) for ovarian cancer by tertile concentrations and for doubling in CRP by tumor characteristics
| Tertiles | ORlog2 (95% CI) | ||||||
|---|---|---|---|---|---|---|---|
| 1 | 2 | 3 | Ptrend1 | phet2 | |||
| Overall | (738 sets) | ||||||
| Unadjusted* | ref. | 0.92 (0.74-1.14) | 0.96 (0.77-1.21) | 0.74 | 1.01 (0.96 - 1.07) | ||
| Multivariable** | ref. | 0.88 (0.70-1.10) | 0.87 (0.68-1.11) | 0.26 | 0.99 (0.93 - 1.05) | ||
| Histology | |||||||
| Serous | (411 sets) | ||||||
| Unadjusted* | ref. | 0.87 (0.65-1.16) | 0.79 (0.58-1.08) | 0.14 | 0.97 (0.90 - 1.05) | ||
| Multivariable** | ref. | 0.85 (0.63-1.13) | 0.76 (0.55-1.06) | 0.10 | 0.97 (0.89 - 1.05) | ||
| Mucinous | (48 sets) | ||||||
| Unadjusted* | ref. | 0.50 (0.18-1.35) | 0.98 (0.43-2.25) | 0.99 | 1.02 (0.84 - 1.25) | ||
| Multivariable** | ref. | 0.53 (0.19-1.50) | 0.84 (0.34-2.08) | 0.70 | 0.99 (0.80 - 1.21) | ||
| Endometrioid | (87 sets) | ||||||
| Unadjusted* | ref. | 0.81 (0.43-1.55) | 1.26 (0.66-2.41) | 0.49 | 1.09 (0.93 - 1.28) | ||
| Multivariable** | ref. | 0.78 (0.40-1.56) | 1.07 (0.52-2.20) | 0.83 | 1.07 (0.88 - 1.29) | ||
| Clear cell | (33 sets) | ||||||
| Unadjusted* | ref. | 1.63 (0.53-5.00) | 0.99 (0.36-2.68) | 0.93 | 1.00 (0.79 - 1.26) | ||
| Multivariable** | ref. | 1.69 (0.46-6.20) | 0.82 (0.25-2.69) | 0.71 | 0.91 (0.68 - 1.23) | ||
| NOS | (127 sets) | ||||||
| Unadjusted* | ref. | 1.45 (0.83-2.55) | 1.67 (0.95-2.92) | 0.08 | 1.09 (0.95 - 1.25) | ||
| Multivariable** | ref. | 1.29 (0.72-2.33) | 1.39 (0.75-2.55) | 0.31 | 1.03 (0.88 - 1.19) | ||
| Other | (32 sets) | ||||||
| Unadjusted* | ref. | 0.67 (0.23-1.92) | 0.54 (0.16-1.75) | 0.30 | 0.99 (0.69 - 1.42) | 0.04* | |
| Multivariable** | ref. | 0.66 (0.22-2.02) | 0.59 (0.16-2.15) | 0.40 | 1.06 (0.71 - 1.58) | 0.05** | |
| Grade | |||||||
| Low Grade | (40 sets) | ||||||
| Unadjusted* | ref. | 0.43 (0.16-1.22) | 1.18 (0.47-2.97) | 0.68 | 1.09 (0.84 - 1.41) | ||
| Multivariable** | ref. | 0.41 (0.14-1.19) | 0.97 (0.35-2.69) | 0.93 | 1.01 (0.75 - 1.36) | ||
| High Grade | (390 sets) | ||||||
| Unadjusted* | ref. | 0.80 (0.60-1.07) | 0.82 (0.60-1.12) | 0.20 | 0.97 (0.90 - 1.04) | 0.53* | |
| Multivariable** | ref. | 0.76 (0.56-1.03) | 0.74 (0.53-1.04) | 0.11 | 0.95 (0.87 - 1.03) | 0.57** | |
| Stage | |||||||
| Low Stage | (100 sets) | ||||||
| Unadjusted* | ref. | 1.16 (0.66-2.05) | 1.25 (0.68-2.27) | 0.46 | 1.09 (0.94 - 1.28) | ||
| Multivariable** | ref. | 1.00 (0.54-1.84) | 1.03 (0.53-1.98) | 0.94 | 1.06 (0.90 - 1.25) | ||
| High Stage | (553 sets) | ||||||
| Unadjusted* | ref. | 0.91 (0.71-1.18) | 0.95 (0.73-1.24) | 0.49 | 1.00 (0.94 - 1.07) | 0.33* | |
| Multivariable** | ref. | 0.88 (0.68-1.15) | 0.87 (0.66-1.15) | 0.90 | 0.98 (0.91 - 1.05) | 0.30** | |
| Type I / Type II | |||||||
| Type I | (77 sets) | ||||||
| Unadjusted* | ref. | 0.50 (0.24-1.04) | 0.98 (0.51-1.92) | 0.81 | 1.02 (0.86 - 1.20) | ||
| Multivariable** | ref. | 0.52 (0.25-1.10) | 0.89 (0.43-1.84) | 0.51 | 0.99 (0.83 - 1.18) | ||
| Type II | (308 sets) | ||||||
| Unadjusted* | ref. | 0.76 (0.55-1.05) | 0.73 (0.51-1.04) | 0.09 | 0.95 (0.87 - 1.03) | 0.46* | |
| Multivariable** | ref. | 0.72 (0.51-1.01) | 0.66 (0.45-0.97) | 0.06 | 0.93 (0.85 - 1.02) | 0.45** | |
Matched for study center, age at blood donation, menopausal status, time of the day of blood collection, fasting status, exogenous hormone use at blood donation and phase of the menstrual cycle
Additionally adjusted for BMI (continuous scale), ever full-term pregnancy (never/ever), age at first birth (continuous scale).
Linear trends based on the median CRP values for tertiles.
Statistical tests for heterogeneity were based on the likelihood-ratio test, comparing the model fit for logistic regression models with and without corresponding interaction term.
Tertile cut-offs: CRP (mg/L): first tertile 0.53 – 1.47; second tertile 1.48-4.01 third tertile: >4.01