Table 4.
Odds ratios (95% CI) for ovarian cancer by tertile concentrations and for doubling in IL-6 by tumor characteristics
| Tertiles | ORlog2 (95% CI) | ||||||
|---|---|---|---|---|---|---|---|
| 1 | 2 | 3 | Ptrend1 | phet2 | |||
| Overall | (741 sets) | ||||||
| Unadjusted* | ref. | 0.94 (0.75-1.17) | 1.12 (0.89-1.41) | 0.34 | 1.11 (1.00 - 1.24) | ||
| Multivariable** | ref. | 0.90 (0.71-1.13) | 1.03 (0.81-1.32) | 0.79 | 1.09 (0.97 - 1.21) | ||
| Histology | |||||||
| Serous | (414 sets) | ||||||
| Unadjusted* | ref. | 0.78 (0.58-1.05) | 0.95 (0.69-1.31) | 0.71 | 1.01 (0.87 - 1.17) | ||
| Multivariable** | ref. | 0.75 (0.56-1.02) | 0.93 (0.67-1.30) | 0.62 | 1.02 (0.87 - 1.19) | ||
| Mucinous | (51 sets) | ||||||
| Unadjusted* | ref. | 1.12 (0.46-2.73) | 1.38 (0.58-3.27) | 0.46 | 1.29 (0.83 - 2.00) | ||
| Multivariable** | ref. | 0.92 (0.35-2.42) | 0.89 (0.33-2.44) | 0.82 | 1.01 (0.60 - 1.69) | ||
| Endometrioid | (86 sets) | ||||||
| Unadjusted* | ref. | 1.44 (0.73-2.83) | 1.58 (0.83-3.02) | 0.17 | 1.24 (0.90 - 1.70) | ||
| Multivariable** | ref. | 1.38 (0.69-2.75) | 1.44 (0.72-2.90) | 0.31 | 1.21 (0.86 - 1.70) | ||
| Clear cell | (33 sets) | ||||||
| Unadjusted* | ref. | 2.18 (0.65-7.24) | 1.39 (0.45-4.33) | 0.65 | 1.31 (0.81 - 2.12) | ||
| Multivariable** | ref. | 1.62 (0.46-5.64) | 0.99 (0.28-3.50) | 0.96 | 1.11 (0.64 - 1.90) | ||
| NOS | (126 sets) | ||||||
| Unadjusted* | ref. | 1.00 (0.57-1.77) | 1.15 (0.67-1.95) | 0.60 | 1.24 (0.98 - 1.57) | ||
| Multivariable** | ref. | 0.91 (0.51-1.64) | 0.92 (0.52-1.63) | 0.80 | 1.15 (0.90 - 1.47) | ||
| Other | (31 sets) | ||||||
| Unadjusted* | ref. | 1.05 (0.29-3.86) | 1.59 (0.50-5.08) | 0.35 | 1.15 (0.67 - 1.95) | 0.06* | |
| Multivariable** | ref. | 1.04 (0.23-4.73) | 1.37 (0.38-4.99) | 0.57 | 1.08 (0.58 - 2.02) | 0.07** | |
| Grade | |||||||
| Low Grade | (40 sets) | ||||||
| Unadjusted* | ref. | 0.47 (0.17-1.32) | 0.30 (0.09-1.04) | 0.36 | 0.64 (0.36 - 1.15) | ||
| Multivariable** | ref. | 0.39 (0.13-1.15) | 0.22 (0.05-0.87) | 0.22 | 0.52 (0.26 - 1.02) | ||
| High Grade | (391 sets) | ||||||
| Unadjusted* | ref. | 0.89 (0.65-1.21) | 1.10 (0.81-1.51) | 0.58 | 1.03 (0.89 - 1.21) | 0.17* | |
| Multivariable** | ref. | 0.85 (0.62-1.17) | 1.04 (0.75-1.44) | 0.67 | 1.01 (0.86 - 1.19) | 0.17** | |
| Stage | |||||||
| Low Stage | (103 sets) | ||||||
| Unadjusted* | ref. | 1.37 (0.75-2.52) | 1.15 (0.63-2.07) | 0.62 | 1.23 (0.93 - 1.63) | ||
| Multivariable** | ref. | 1.35 (0.72-2.54) | 1.07 (0.56-2.03) | 0.81 | 1.21 (0.89 - 1.64) | ||
| High Stage | (551 sets) | ||||||
| Unadjusted* | ref. | 0.87 (0.67-1.12) | 1.10 (0.84-1.44) | 0.49 | 1.07 (0.94 - 1.21) | 0.39* | |
| Multivariable** | ref. | 0.82 (0.63-1.07) | 1.02 (0.76-1.36) | 0.90 | 1.04 (0.91 - 1.19) | 0.39** | |
| Type I / Type II | |||||||
| Type I | (80 sets) | ||||||
| Unadjusted* | ref. | 0.85 (0.42-1.71) | 0.82 (0.40-1.67) | 0.88 | 0.94 (0.66 - 1.35) | ||
| Multivariable** | ref. | 0.68 (0.32-1.44) | 0.62 (0.28-1.39) | 0.47 | 0.79 (0.52 - 1.19) | ||
| Type II | (309 sets) | ||||||
| Unadjusted* | ref. | 0.85 (0.61-1.20) | 0.99 (0.69-1.41) | 0.91 | 0.95 (0.80 - 1.14) | 0.96* | |
| Multivariable** | ref. | 0.81 (0.57-1.15) | 0.95 (0.65-1.39) | 0.99 | 0.95 (0.78 - 1.14) | 0.94** | |
Matched for study center, age at blood donation, menopausal status, time of the day of blood collection, fasting status, exogenous hormone use at blood donation and phase of the menstrual cycle.
Additionally adjusted for BMI (continuous scale), ever full-term pregnancy (never/ever), age at first birth (continuous scale).
Linear trends based on the median IL-6 values for tertiles.
Statistical tests for heterogeneity were based on the likelihood-ratio test, comparing the model fit for logistic regression models with and without corresponding interaction term.
Tertile cut-offs: IL-6 (pg/mL): first tertile 0.78 – 1.26; second tertile 1.27-2.17 third tertile: >2.17.