Table 3.

Studies of microtubule-associated protein 2 immunoreactivity in schizophrenia.

Study	N of Subjects SZ/C	Region	Antibody Name	Antibody Phospho- dependence	Antibody Isoform specificity	Finding(s)
Arnold et al. 1991 [39]	6/12	Hippocampus and associated areas^a	AP14 AP18 M12, T24, T34, T39, T42	Independent Dependent Unknown	HMW All Unknown	Decreased MAP2-IR in the subiculum of 83% of SZ subjects and entorhinal cortex of 67% of SZ subjects
Bouras et al. 2001 [44]	44/55	BA 24	AP14 AP18	Independent Dependent	HMW All	No difference in MAP2-IR using quantitative immunodot analysis
Cotter et al. 1997 [45]	8/11	Hippocampus	972 305	Independent Dependent	All All	Increase in non-phosphorylated MAP2- IR in left subiculum and left CA1 in SZ subjects
Cotter et. al 2000 [46]	12/13	Hippocampus	B9 972	Independent Independent	All All	Increase in dendritic arborization in hippocampal regions CA1, CA2, CA3, and CA4 in SZ subjects
Jones et al. 2002 [40]	7/7	BA 9 BA 32	Anti-MAP2^b	Unknown	Unknown	MAP2 area fraction is reduced by 40% in layer 3 and 45% in layer 5 of BA 9 in SZ subjects. MAP2 area fraction is reduced by 32% in layer 3 and 44% in layer 5 of BA 32 in SZ subjects
Rosoklija et al. 2005 [42]	64/47	Hippocampus and associated areas	Anti-MAP2	Independent	HMW	Decreased MAP2-IR in subiculum of 20% of SZ subjects
Rioux et al. 2004 [41]	11/7	Olfactory bulb	AP18 Clone C	Dependent Independent	All All	Significant reduction in MAP2-IR in SZ subjects
Somenarain et al. 2010 [43]	8/8	BA 9	Anti-MAP2	Independent	HMW	MAP2 area fraction is reduced by 39% in layer 3 and 38% in layer 5 in SZ subjects
Shelton et al., 2013 [19]	20/20	BA 41	SMI-52	Independent	All	MAP2-IR is reduced by 70% in BA41 deep layer 3. MAP2-IR below lowest value observed in any control subject in 60% of SZ subjects

Associated areas refers to subiculum, parahippocampal cortex, and entorhinal cortex

Anti-MAP2 here refers to the binding target of the antibody and is not meant to suggest that all antibodies termed anti-MAP2 are identical.

Abbreviations: BA- Brodmann area; SZ- schizophrenia; C- control; HMW- high molecular weight MAP2 isoforms (MAP2A, MAP2B); MAP2-IR- MAP2 Immunoreactivity; CA1, CA2, CA3, CA4- Cornu Ammonis areas 1–4.