Figure 5.
Inhibition of replicon initiation by UVC or UVA–UVB. Velocity sedimentation analysis of nascent DNA from NHF1 cells exposed to low fluences of a) UVC (1 J m−2 open squares; sham control-closed diamonds) or b) UVA–UVB (3.8 kJ m−2 open squares; sham control-closed diamonds). Fluences were chosen so as to induce similar CPD densities (~19 CPD/Mb). Inhibition of small MW DNA, measured from the area under the curve between the two arrows, was 34% ± 6% (UVA–UVB) and 40% ± 7% (UVC), n = 3 (mean ± SEM), and these values were not statistically different (P = 0.4, Wilcoxon rank-sum test).
