Table 1.
Demographic, physical, biochemical, and imaging characteristics of the study participants
| Training Cohort (n = 102) | Validation Cohort (n = 102) | P-Values | |
|---|---|---|---|
| Demographics | |||
| Male (%)^ | 40 | 38 | 0.886 |
| Age (years)* | 51.3 ± 17.2 | 49.0 ± 16.6 | 0.344 |
| Height (cm)* | 165.5 ± 10.3 | 166.8 ± 9.5 | 0.375 |
| Weight (kg)* | 85.1 ± 21.0 | 84.4 ± 20.1 | 0.809 |
| BMI (kg/m2)* | 30.9 ± 6.4 | 30.2 ± 6.1 | 0.432 |
| Ethnic origin (%)^ | 0.671 | ||
| White | 47 | 48 | - |
| Hispanic | 31 | 26 | - |
| Asian | 14 | 16 | - |
| Black | 4 | 4 | - |
| Other | 4 | 6 | - |
| Diabetes^ | 42 | 47 | 0.573 |
| Biochemical profile* | |||
| Hemoglobin (g/dL) | 13.7 ± 1.6 | 14.0 ± 1.5 | 0.086 |
| Hematocrit (%) | 40.3 ± 4.1 | 41.5 ± 3.8 | 0.042 |
| Platelet count (×10^3/uL) | 251 ± 72 | 255 ± 66 | 0.676 |
| AST (U/L) | 34.1 ± 26.9 | 34.4 ± 36.2 | 0.945 |
| ALT (U/L) | 41.9 ± 36.7 | 43.5 ± 55.3 | 0.814 |
| Alkaline phosphatase (U/L) | 76.2 ± 28.1 | 73.9 ± 23.3 | 0.526 |
| GGT (U/L) | 44.6 ± 45.6 | 41.3 ± 44.9 | 0.596 |
| Total bilirubin (mg/dL) | 0.5 ± 0.4 | 0.5 ± 0.3 | 0.861 |
| Albumin (g/dL) 4.5 ± 0.4 | 4.9 ± 3.9 | 0.320 | |
| Glucose (mg/dL) | 105.5 ± 46.5 | 109.8 ± 48.4 | 0.523 |
| Triglycerides (mg/dL) | 145.3 ± 81.0 | 163.0 ± 275.3 | 0.538 |
| Total Cholesterol (mg/dL) | 182.9 ± 41.1 | 180.0 ± 45.5 | 0.645 |
| HDL (mg/dL) | 54.8 ± 20.8 | 53.8 ± 15.6 | 0.717 |
| LDL (mg/dL) | 101.1 ± 31.8 | 96.6 ± 30.4 | 0.308 |
| INR | 1.0 ± 0.2 | 1.0 ± 0.2 | 0.572 |
| Imaging* | |||
| MRI-PDFF 5–8 (%) | 11.4 ± 9.0 | 10.7 ± 8.2 | 0.5365 |
| BSC (1/cm-sr) | 0.026 ± 0.046 | 0.018 ± 0.030 | 0.1517 |
Abbreviations for table: AST, aspartate aminotransferase; ALT, alanine aminotransferase; BSC, backscatter coefficient; BMI, body mass index; GGT, gamma-glutamyl transpeptidase; HDL, high-density lipoprotein; INR, international normalized ratio; LDL, low-density lipoprotein; MRI, magnetic resonance imaging; PDFF, proton-density-fat-fraction (mean calculated from segments 5–8). All labs were measured while patients were fasting.
Mean value provided with standard deviations and p-values (t-test).
Chi-square test p-values are presented; note that the chi-square test for comparing ethnic proportions in the two groups were conducted for Whites versus Hispanics versus Asians/Blacks/Others.