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. 2015 Jun 3;10(6):e0127032. doi: 10.1371/journal.pone.0127032

Fig 2. The effect of genetic modification of heparanase on neutrophil recruitment to the lung.

Fig 2

The total number of inflammatory cells (A, C) and neutrophils (B, D) recruited to the lung following acute exposure of wild-type (WT), and Hpa-/- mice to intranasal (i.n.) saline, zymosan (A, B) or LPS (C, D). Data presented as box plots (median, 25–75 percentile) with whiskers representing 5–95% confidence interval. The number of animals represented by box plots in each panel is as follows; Panel A, B: Saline treated group (WT; n = nil ♀, 5 ♂; Hpa-/-, n = 2 ♀, 1 ♂) and zymosan treated group (WT; n = 4 ♀, 4 ♂; Hpa-/-, n = 3 ♀, 4 ♂). *p < 0.05 compared with saline; †No significant difference compared with WT zymosan. Panel C, D: Saline treated group (WT: wild type; n = 2 ♀, 3 ♂; Hpa-/-, n = 3 ♀) and LPS treated group (WT; n = 5 ♀; Hpa-/-, n = 4 ♀). *p < 0.05 compared with saline; †No significant difference compared with WT LPS. Data obtained from one experiment.