Table 2. Allele frequency distribution between the ESCC and control populations.

SNP name	Gene locus	Location	Function	Major/major allele	Major/minor allele	Minor/minor allele	No. of Major/major alleles in cases	No. of Major/minor alleles in cases	No. of Minor/minor alleles in cases	No. of Major/major alleles in controls	No. of Major/minor alleles in controls	No. of Minor/minor alleles in controls	X2 test (Hardy-Weinberg test for controls)	P value ((Hardy-Weinberg test for controls))	P (Fisher’s test)
rs3805322	ADH4	100056998	Intron region	AA	AG	GG	236	256	123	125	246	141	0.744	0.689	0.000
rs4822983	CHEK2	28719078	Intron region	CC	CT	TT	358	226	32	324	166	23	0.087	0.957	0.225
rs10082466	MBL2	52766862	3'-UTR	AA	AG	GG	437	161	15	369	147	13	0.621	0.733	0.844
rs1152620	MALAT1	65489858	N/A	AA	AG	GG	188	120	303	149	112	267	161.733	<0.001	0.6
rs11548103	S100A14	52766862	3'-UTR	GG	AG	AA	49	286	278	58	231	239	0.038	0.981	0.198
rs11716316	ABI3BP	100764451	Intron region	AA	AC	CC	188	138	286	150	117	262	152.489	<0.001	0.6
rs9327870	ABI3BP	102667853	N/A	TT	TC	CC	186	258	85	218	281	115	2.079	0.353	0.426
rs12904	EFNA1	155134221	Near Gene-5	AA	AG	GG	451	152	11	393	125	11	0.082	0.959	0.862
rs1321311	CDKN1A	36655123	N/A	GG	GT	TT	425	166	16	364	146	16	0.085	0.958	0.901
rs17618244	KLB	39446909	Missense	GG	AG	AA	415	175	23	372	139	18	1.234	0.54	0.634
rs2073498	RASSF1A	50332115	Missense	CC	CA	AA	530	81	4	461	64	5	2.614	0.271	0.74
rs2114358	miR-1206	128008933	Intron region	TT	TC	CC	314	181	32	339	238	37	0.315	0.854	0.194
rs2285947	DNAH11	21544470	Intron region	GG	GA	AA	263	284	66	232	235	58	0.017	0.991	0.869
rs351855*	FGFR	177093242	Missense	TT	CT	CC	402	5	191	334	14	146	430.686	<0.001	0.035
rs4072037	MUC1	155192276	Cds-synonymous	AA	AG	GG	383	127	15	441	150	17	0.945	0.623	0.982
rs550894	miR-612	65444469	ncRNA	GG	GT	TT	342	238	31	282	208	35	0.163	0.922	0.466
rs699517	TYMS	673016	3'-UTR	TT	CT	CC	259	287	67	236	240	53	0.499	0.779	0.698
rs8191664	NEIL2	11786044	Missense	GG	GT	TT	400	191	22	355	148	25	3.382	0.184	0.431

Abbreviations: ESCC, esophageal squamous cell carcinoma; SNP, single nucleotide polymorphism; OR, odds ratio; CI, confidence interval.

* Because the number of heterozygous alleles was too small, the P values for comparisons of major/major allele vs. major/minor allele vs. minor/minor allele were not sufficiently persuasive. The comparisons of TT+CT versus CC or TT versus CT+CC were not significant. Thus, we did not further evaluate this SNP.