Table 4. Risk of ESCC associated with the rs3805322 (ADH4) and rs4822983 (CHEK2) SNPs by smoking status and drinking history in the Jinan set.
| Variable | ADH4 rs3805322 | P interaction 2 | CHEK2 rs4822983 | P interaction 2 | ||||||
|---|---|---|---|---|---|---|---|---|---|---|
| No. of AA | No. of AG+GG | OR 1 (95% CI) | P | No. of CC | No. of CT+TT | OR 1 (95% CI) | P | |||
| Smoking status | 0.939 | 0.366 | ||||||||
| No | 112/169 | 74/96 | 0.86 (0.58–1.27) | 0.443 | 143/197 | 97/102 | 0.76 (0.54–1.09) | 0.132 | ||
| Yes | 204/181 | 104/150 | 0.78 (0.57–1.08) | 0.131 | 173/153 | 127/98 | 0.87 (0.62–1.23) | 0.434 | ||
| Drinking status | 0.085 | 0.302 | ||||||||
| No | 87/90 | 153/209 | 1.32 (0.92–1.90) | 0.131 | 112/169 | 74/96 | 0.86 (0.58–1.27) | 0.443 | ||
| Yes | 116/49 | 184/202 | 2.59 (1.76–3.84) | <0.001 | 204/181 | 150/104 | 0.78 (0.57–1.08) | 0.131 | ||
Abbreviations: ESCC, esophageal squamous cell carcinoma; SNP, single nucleotide polymorphism; No., Number; OR, odds ratio; CI, confidence interval.
1 Logistic regression was used to evaluate the data adjusted for numerous variables, including age, sex, and smoking and drinking status.
2 The multiplicative interaction term was used to calculate P values for gene-environment interactions