Table 4.

Summary of Cycle 1 IMC-A12 Pharmacokinetic (PK) Parameters

IMC-A12 Dose Temsirolimus Dose	6 mg/kg 8 mg/m2 (n=8)		6 mg/kg 10 mg/m2 (n = 3)		6 mg/kg 15 mg/m2 (n = 4)
	Median	Range	Median	Range	Median	Range
Cmax (μg/mL)	281	(239–355)	277	(219–390)	230	(161–464)
Tmax (h)	2.0	(1.0–7.0)	1.1	(1.1–2.2)	2.1	(1.1–7.0)
t1/2 (h)	98	(64–161)	122	(88–133)	130	(98–446)
AUC0–7d (h•μg/L)	20.6	(11.6–29.7)	25.6	(20.6–28.7)	26.4	(14.8–34.0)
CL (mL/h)	8.3	(1.1–15.2)	9.9	(2.9–14.5)	7.0	(3.1–14.3)
CL (mL/h/kg)	0.19	(0.12–0.43)	0.17	(0.12–0.18)	0.13	(0.07–0.24)
Vdss (mL)	1050	(150–2390)	1750	(470–1840)	1860	(590–2400)
Vdss (mL/kg)	25.8	(20.8–40.3)	22.7	(20.7–29.4)	31.1	(18.6–42.3)