Table 4.

Regression Coefficients Between Changes in BMD (24 Months—Baseline) and Clinical Parameters and Biomarkers

	Men (n = 46–108)				Premenopausal Women (n = 28–29)				Postmenopausal Women (n = 55–100)				Sex × Predictor
	ΔSpine BMD (24–0)	P Value	ΔFN BMD (24–0)	P Value	ΔSpine BMD (24–0)	P Value	ΔFN BMD (24–0)	P Value	ΔSpine BMD (24–0)	P Value	ΔFN BMD (24–0)	P Value	Spine BMD	FN BMD
Age	−0.0001	.731	0.0003	.359	−0.0003	.825	−0.0008	.502	0.0004	.537	0.0003	.659	0.265	0.968
Baseline data
Weight, kg	0.0002	.547	−0.0005	.076	−0.00002	.976	0.0001	.908	0.0001	.697	0.0001	.766	0.462	0.292
BMI	0.0007	.503	−0.0015	.102	0.0003	.868	0.0014	.459	0.0009	.299	0.0008	.353	0.987	0.096
Waist circumference, cm	0.0001	.783	−0.0006	.065	−0.0004	.546	0.0002	.775	0.0004	.270	−0.0002	.645	0.974	0.580
Body fat, %	−0.0009	.229	−0.0001	.861	0.0001	.972	0.0002	.927	0.0005	.551	0.0001	.880	0.057	0.575
FMI	−0.0006	.671	−0.0011	.413	−0.0001	.972	0.0019	.527	−0.0005	.551	0.007	.560	0.164	0.253
LM, %	0.0009	.229	0.0001	.861	−0.0001	.972	−0.0002	.927	−0.0005	.551	−0.0001	.880	0.057	0.575
LMI	0.0033	.076	−0.0035	.043	0.0007	.844	0.0025	.486	0.0018	.357	0.0026	.205	0.198	0.097
Fat/LM ratio	−0.0405	.258	−0.0039	.907	−0.0006	.993	0.0105	.888	0.0161	.542	0.0086	.975	0.040	0.606
VATa	0.0016	.629	−0.0042	.111	N/Aa	N/Aa	N/Aa	N/Aa	0.0045	.131	−0.0015	.624	0.507	0.514
SATa	0.0026	.156	−0.0024	.099	N/Aa	N/Aa	N/Aa	N/Aa	−0.0013	.473	0.0003	.871	0.130	0.264
Physical activity	0.0304	.393	0.0303	.368	−0.0584	.463	0.1044	.189	−0.0165	.576	0.0399	.187	0.282	0.911
Follow-up data (24–0 mo)
ΔWeight	−0.0010	.006	0.0003	.322	−0.0001	.933	0.0032	.010	0.0016	.004	0.0022	<.0001	<0.0001	0.001
ΔBMI	−0.0032	.005	0.0011	.287	−0.0003	.941	0.0083	.011	0.0042	.004	0.0061	<.0001	<0.0001	0.003
ΔWaist circumference	−0.0008	.024	0.0004	.231	0.00005	.962	0.0017	.108	0.0009	.086	0.0015	.004	0.006	0.049
ΔBody fat, %	−0.0004	.026	0.0001	.444	−0.0001	.877	0.0013	.024	0.0007	.006	0.0011	<.0001	0.0004	<0.001
ΔFMI	−0.0037	.027	0.0014	.365	−0.0003	.952	0.0105	.015	0.0053	.007	0.0080	<.0001	0.0004	0.006
ΔLM, %	0.0004	.026	0.0006	.328	0.0001	.877	0.0039	.044	0.0007	.006	0.0029	<.001	<0.0001	0.025
ΔLMI	−0.0100	.001	0.003	.248	−0.0017	.869	0.0194	.0502	0.0119	.011	0.0149	.002	<0.0001	0.019
ΔFM/LM mass ratio	−0.0613	.171	0.0325	.444	−0.0012	.987	0.1909	.030	0.0996	.016	0.1619	<.0001	0.007	0.026
ΔVAT	−0.0060	.063	0.0017	.523	N/A*	N/A*	N/A*	N/A*	0.0120	.031	0.0230	<.0001	0.007	<0.001
ΔSAT	−0.0086	.003	0.00002	.995	N/A*	N/A*	N/A*	N/A*	0.0062	.037	0.0101	.0002	0.0003	0.005
ΔPhysical activity	0.0557	.152	0.0011	.976	0.0717	.414	−0.0835	.346	0.0672	.047	−0.0520	.139	0.863	0.310

Abbreviations: SAT, sc adipose tissue; N/A, not available. Menopausal status was self-reported at enrollment.

^aFor CT measures (VAT and SAT), n = 42 postmenopausal women, 0 premenopausal women, and 55 men.