Table 2.
Concentrations of Estrogens and Their Metabolites in Lean and Obese Prepubertal Girls Median (Interquartile Range) Levels in Picograms per Millilitera
| Lean | Obese | P Valueb | |
|---|---|---|---|
| E2 | 0.5 (.5, 2.37) | 3.45 (0.5, 4.65) | .04 |
| Estriol (16α-OH-E2) | 6.97 (2.77, 10.07) | 5.0 (0.5, 8.32) | .134 |
| 4-MeO-E2 | 1.85 (0.62, 2.12) | 2.12 (0.5, 5.75) | .462 |
| 2-Methoxyestradiol (2-MeO-E2) | 0.628 (0.5, 1.29) | 0.5 (0.5, 0.5) | .012 |
| E1c | 53.12 (31.7, 126.79) | 49.17 (23.79, 77.42) | .266 |
| 16α-OH-E1 | 0.5 (0.5, 0.91) | 7.17 (0.5, 9.64) | .007 |
| 4-Methoxyestrone (4-MeO-E1) | 0.5 (0.5, 1.72) | 0.5 (0.5, 0.5) | .426 |
| 2-Methoxyestrone (2-MeO-E1) | 0.72 (0.49, 1.97) | 0.5 (0.5, 2.68) | .859 |
| 4-OH-estradiol (4-OH-E2) | 0.5 (0.5, 0.5) | 0.5 (0.5, 0.5) | NS |
| 2-OH-estradiol (2-OH-E2) | 0.5 (0.5, 0.5) | 0.5 (0.5, 0.5) | NS |
| 4-OH-estrone (4-OH-E1) | 0.5 (0.5, 0.5) | 0.5 (0.5, 0.5) | NS |
| 2-OH-estrone (2-OH-E1) | 1.56 (0.5, 3.44) | 0.5 (0.5, 7.9) | 0.971 |
Bold denotes statistical significance.
a
SI unit conversion: for picomoles per liter, multiply E2 by 3.671; 16α-OH-E2, 4-OH-E2, and 2-OH-E2 by 3.467; 4-MeO-E2 and 2-MeO-E2 by 3.307; E1 by 3.698; 16α-OH-E1, 4-OH-E1, and 2-OH-E1 by 3.492; and 4-MeO-E1, and 2-MeO-E1 by 3.329.
b
Mann-Whitney U test.
c
The E1 values represent the total conjugated and unconjugated steroid after glucuronidase/sulfatase hydrolysis, whereas the levels of all other steroids represent the free fractions.