Figure 1.

Details of study design. A, Overview of the study protocol depicting the timing of the stable isotope infusions, euglycemic-hyperinsulinemic clamp, and magnetic resonance studies. B, Four participants started with the complex carbohydrate diet followed by the high-fructose diet; the other four were fed the diets in the opposite sequence. C, Both diets had identical energy and macronutrient content; the complex carbohydrate diet had a very low fructose content (5% of total energy intake) whereas fructose accounted for half of the total carbohydrate intake on the high-fructose diet (25% of total energy intake).