Table 1.

Effects of CCHO Versus High-fructose Diet on Lipid and Glucose Metabolism

	CCHO Diet	High-fructose Diet	P Value
	Fasting lipids, mg/dL
Total cholesterol	166 ± 10	167 ± 11	.83
LDL cholesterol	107 ± 8	109 ± 10	.69
HDL cholesterol	39 ± 2	38 ± 2	.49
Triglycerides	102 ± 7	100 ± 7	.67
Fasting glucose, mg/dL	75.2 ± 0.8	77.3 ± 0.9	.21
Glucose during clamp; last 30 min, mg/dL	75.3 ± 1.4	75.0 ± 1.6	.48
Fasting insulin, μU/mL	8.8 ± 0.9	9.0 ± 1.1	.85
Insulin during clamp; last 30 min, μU/mL	77.5 ± 4.7	83.2 ± 4.8	.21
Total glucose uptake during clamp, mg/kg per min per μU/dL	9.49 ± 1.50	10.33 ± 1.07	.25
Glucose oxidation by indirect calorimetry, mg/kg/min
Fasting	1.50 ± 0.26	1.50 ± 0.18	.98
Hyperinsulinemic clamp	2.79 ± 0.28	2.69 ± 0.39	.79
Nonoxidative glucose disposal	51%	66%
Endogenous glucose production, Ra glucose; mg/kg/min
Fasting	1.70 ± 0.08	1.95 ± 0.17	.11
Hyperinsulinemic clamp	0.46 ± 0.06	0.60 ± 0.07	.01
Suppression by insulin	71%	66%
Gluconeogenesis, mg/kg per min
Fasting	0.56 ± 0.04	0.56 ± 0.04	.96
Hyperinsulinemic clamp	0.02 ± 0.004	0.02 ± 0.004	.83
Suppression by insulin	96%	96%
Glycogenolysis, mg/kg per min
Fasting	1.14 ± 0.06	1.39 ± 0.14	.06
Hyperinsulinemic clamp	0.44 ± 0.06	0.58 ± 0.06	.01
Suppression by insulin	60%	54%

Abbreviations: HDL, high-density lipoprotein; Ra, rate of appearance.

Data are mean ± sem. P-values by paired t test.