Figure 2.

Conserved subnetworks. (A) A sub-network consisting of interactions identified by matching interologs in at least 4 (out of 13) reference species. The majority of proteins were found in a single connected network, with several smaller unconnected subnetworks. (B) A more stringent subnetwork of interactions with at least 5 interolog reference species. Clear clusters were concentrated in an organic layout by having more inter-group connections than between-group connections. These clusters consisted primarily of proteins with the same biological role, indicated by dotted circles. One such cluster (C) was an unconnected subnetwork consisting entirely of members of the COP9 signalosome. EIF3, elongation initation factor complex 3; U2, U2 splicosome; MCM, mini-chromosome maintenance proteins complex.